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The approximate plasma half-life of fludrocortisonefluorohydrocortisoneis 3.5 hours or more and the biological half-life is 18 to 36 hours.

When administered concurrentlythe following drugs may interact with adrenal corticosteroids.

0.1mg TabletsFludrocortisone acetate 0.1mg TabletsFludrocortisone acetate)

Corticosteroids may mask some signs of infectionand new infections may appear during their useThere may be decreased resistance and inability to localize infection when corticosteroids are usedIf an infection occurs during fludrocortisone acetate therapyit should be promptly controlled by suitable antimicrobial therapy.

Corticosteroids are found in the breast milk of lactating women receiving systemic therapy with these agentsCaution should be exercised when fludrocortisone acetate is administered to a nursing woman.

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