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AThere is a moderate drug-drug interaction between Wellbutrin and CymbaltaTopamaxSeroquel and Klonopinwhich results in a lowering of the seizure thresholdThe risk of seizures may be increased in patients with a history of head trauma or prior seizureCNS tumorsevere hepatic cirrhosisexcessive use of alcohol or sedativesaddiction to opiatescocaineor stimulantsuse of over-the-counter stimulants and anorecticsa total daily dose of Wellbutrin greater than 450 mg or single doses greater than 150 mgrapid escalation of bupropion dosagediabetics treated with oral hypoglycemics or insulinor with concomitant medications known to lower seizure thresholdantipsychoticstheophyllinesystemic steroidsThe adverse effects associated with Wellbutrin are dry mouthnauseainsomniatremorexcessive sweatingrash and tinnitusAs with any medication of this typediscuss how to appropriately discontinue treatment with Wellbutrin with your physicianA gradual dosage decrease is preferable to just stopping the medicationI do not know your medical history to advise you if depression will returnFor immediate questions or concernsplease contact your physicianJoseph HallRPh.

QI have had lapband surgery and must crush my medicationsI can tolerate all my medicationsexcept Wellbutrinwhich tastes horrible crushedI have tried flat sodajuiceapplesauceand ice cream nothing seems to cut the tasteAny ideas?

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